abstract：:The aim of this study was to examine correlations between vaginal inflammatory cytokines (IL-1alpha, IL-1beta, IL-6 and IL-8) and pregnancy-related traits (gestational age, birth-weight, BMI, weight gain during pregnancy and vaginal pH). Differences in correlation coefficients were examined among bacterial vaginosis (...

journal_title：Journal of reproductive immunology

authors： Ryckman KK,Williams SM,Kalinka J

更新日期：2008-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan degradation along the kynurenine pathway, and is hypothesized to limit tryptophan availability at embryo implantation and prevent maternal T cell activation at the maternal-fetal interface. To determine if nonhuman primates ar...

journal_title：Journal of reproductive immunology

authors： Drenzek JG,Breburda EE,Burleigh DW,Bondarenko GI,Grendell RL,Golos TG

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Mice disrupted for the interleukin (IL)-18 gene appear more disposed to preterm delivery (PTD) induced by inflammation. A synergy between IL-18 and IL-12 has been suggested. The objective of this study was to investigate a possible relation between human maternal serum levels of IL-18, IL-12 and spontaneou...

journal_title：Journal of reproductive immunology

authors： Ekelund CK,Vogel I,Skogstrand K,Thorsen P,Hougaard DM,Langhoff-Roos J,Jacobsson B

更新日期：2008-04-01 00:00:00

abstract：:Few studies have assessed longitudinal changes in circulating cytokine levels during normal pregnancy. We have examined the natural history of maternal plasma cytokines from early- to mid-pregnancy in a large, longitudinal cohort. Multiplex flow cytometry was used to measure interleukin (IL)-2, IL-6, IL-12, tumor necr...

journal_title：Journal of reproductive immunology

authors： Curry AE,Vogel I,Skogstrand K,Drews C,Schendel DE,Flanders WD,Hougaard DM,Thorsen P

更新日期：2008-04-01 00:00:00

abstract：:Prolactin (PRL) was originally identified by its ability to stimulate mammary development and lactation, and its essential roles other than lactation have recently been implicated in female reproduction. However, little is known about PRL-mediated events in pregnancy. The tryptophan catabolism enzyme indoleamine 2,3-d...

journal_title：Journal of reproductive immunology

authors： Kawaguchi R,Shimokawa T,Umehara N,Nunomura S,Tanaka T,Ra C

更新日期：2008-04-01 00:00:00

abstract：:The association of persistent presence of circulating antiphospholipid antibodies and thromboembolic events, (recurrent) pregnancy loss or both is termed antiphospholipid syndrome. Pregnancies in women with the syndrome should be regarded as at high-risk for complications. Optimal management consisting of close follow...

journal_title：Journal of reproductive immunology

authors： Derksen RH,de Groot PG

更新日期：2008-01-01 00:00:00

abstract：:Immunological abnormalities of cell-mediated and humoral immunity might be associated with the pathogenesis of endometriosis. This study has examined the effects of peritoneal fluid obtained from patients with endometriosis (ePF) on the phenotypic characteristics of macrophages and dendritic cells (DCs) derived from m...

journal_title：Journal of reproductive immunology

authors： Na YJ,Jin JO,Lee MS,Song MG,Lee KS,Kwak JY

更新日期：2008-01-01 00:00:00

abstract：:HIV is generally sexually acquired across the genital or rectal mucosa after exposure to the genital secretions of an HIV-infected partner. Most exposures to HIV do not result in infection, likely due to protection afforded by an intact mucosal epithelium, as well as by innate and adaptive mucosal immune factors prese...

journal_title：Journal of reproductive immunology

authors： Kaul R,Pettengell C,Sheth PM,Sunderji S,Biringer A,MacDonald K,Walmsley S,Rebbapragada A

更新日期：2008-01-01 00:00:00

abstract：:In this review, we summarize the results of a number of our recent in vitro and in vivo experiments demonstrating that, in addition to the immunoregulatory functions, soluble HLA-G molecules also affect endothelial cell activity. We have found that soluble HLA-G1 (also designated HLA-G5) inhibits endothelial cell prol...

journal_title：Journal of reproductive immunology

authors： Le Bouteiller P,Fons P,Herault JP,Bono F,Chabot S,Cartwright JE,Bensussan A

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare serum levels of leptin in women with unexplained infertility with fertile subjects. MATERIAL AND METHOD:Serum leptin levels of 27 infertile and 30 fertile women on day 3 of the menstrual cycle were assessed and compared in this prospective age and body mass index (BMI)...

journal_title：Journal of reproductive immunology

authors： Demir B,Guven S,Guven ES,Atamer Y,Gunalp GS,Gul T

更新日期：2007-10-01 00:00:00

abstract：PROBLEM:Placental abruption is a potential life-threatening condition for both the fetus and the mother, being significantly more common in pregnancies with male fetuses. The pathogenesis of placental abruption remains unknown. However, some recent reports point toward a maternal immune response against the fetus as a ...

journal_title：Journal of reproductive immunology

authors： Nielsen HS,Mogensen M,Steffensen R,Kruse C,Christiansen OB

更新日期：2007-08-01 00:00:00

abstract：:Currently, different approaches are used to select oocytes for in vitro fertilization (IVF) procedures, but they do not assure a significant association with the pregnancy outcome. Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker of elevated implantation rat...

journal_title：Journal of reproductive immunology

authors： Rizzo R,Fuzzi B,Stignani M,Criscuoli L,Melchiorri L,Dabizzi S,Campioni D,Lanza F,Marzola A,Branconi F,Noci I,Baricordi OR

更新日期：2007-06-01 00:00:00

abstract：:Blastocyst implantation is dependent on the differentiation of endometrial stromal cells (ESC) into decidual cells. Decidualization of human ESC in vitro is enhanced by interleukin 11 (IL11), with associated changes in gene expression. Genes downstream of IL11 may provide targets for the treatment of implantation fail...

journal_title：Journal of reproductive immunology

authors： White CA,Dimitriadis E,Sharkey AM,Stoikos CJ,Salamonsen LA

更新日期：2007-02-01 00:00:00

abstract：:Menstrual toxic shock syndrome (mTSS) is an acute systemic inflammatory disease associated with the superantigenic exotoxin, toxic shock syndrome toxin (TSST)-1, produced by Staphylococcus aureus and the use of high absorbency tampons. Even though S. aureus is capable of elaborating several other superantigenic exotox...

journal_title：Journal of reproductive immunology

authors： Rajagopalan G,Smart MK,Murali N,Patel R,David CS

更新日期：2007-02-01 00:00:00

abstract：:A successful pregnancy is characterised by an increase in Th2 cytokines and suppression of Th1 cytokine production. A Th1 to Th2 cytokine shift is also observed in the disease progression of HIV infection. Highly active antiretroviral therapy (HAART) suppresses HIV viremia, increases CD4+ cell counts and counteracts t...

journal_title：Journal of reproductive immunology

authors： Fiore S,Newell ML,Trabattoni D,Thorne C,Gray L,Savasi V,Tibaldi C,Ferrazzi E,Clerici M

更新日期：2006-06-01 00:00:00

abstract：:CD14, the major receptor for bacterial lipopolysaccharide (LPS) as well as other microbial antigens, is a component of the innate immune system. We hypothesized that a single nucleotide C>T polymorphism at position -159 in the CD14 gene that results in elevated CD14 production would influence susceptibility to preterm...

journal_title：Journal of reproductive immunology

authors： Kalish RB,Vardhana S,Normand NJ,Gupta M,Witkin SS

更新日期：2006-06-01 00:00:00

abstract：:Mammalian pregnancy is a complex phenomenon allowing the maternal immune system to support its allogeneic fetus. Physiological pathways protecting the fetus from rejection are thought to be comparable with those leading to allograft acceptance. Heme oxygenase (HO)-1 is known to protect locally against rejection in tra...

journal_title：Journal of reproductive immunology

authors： Zenclussen ML,Anegon I,Bertoja AZ,Chauveau C,Vogt K,Gerlof K,Sollwedel A,Volk HD,Ritter T,Zenclussen AC

更新日期：2006-02-01 00:00:00

abstract：:In our earlier study, we have reported the identification and characterization of a 57-kDa sperm membrane protein from human spermatozoa. The protein was found to be localized on the acrosome in acrosome intact spermatozoa and shifted to equatorial region after acrosomal induction. Further, we demonstrated that it pla...

journal_title：Journal of reproductive immunology

authors： Vijayalaxmi G,Raghavan VP,Reddy KV

更新日期：2005-08-01 00:00:00

abstract：:Lipopolysaccharide-binding protein (LBP) is an acute phase protein known to play a central role in the defense against Gram-negative bacteria. It binds lipopolysaccharides of Gram-negative bacteria and, after binding to CD14, the complex signals through Toll-like receptor (TLR)-4, eliciting host-defense responses, suc...

journal_title：Journal of reproductive immunology

authors： Malm J,Nordahl EA,Bjartell A,Sørensen OE,Frohm B,Dentener MA,Egesten A

更新日期：2005-06-01 00:00:00

abstract：:During the past decade, accumulated evidence indicates an association between endometriosis and an alteration of humoral and cell-mediated immunity. While the role of L-carnitine in the regulation of energy metabolism is well established, it is only recently that L-carnitine has been recognized to modify the immune re...

journal_title：Journal of reproductive immunology

authors： Dionyssopoulou E,Vassiliadis S,Evangeliou A,Koumantakis EE,Athanassakis I

更新日期：2005-04-01 00:00:00

abstract：:This study has assessed the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine administered to intact domestic cats. Fifteen kittens, 8-9 weeks of age, were allocated to three unequal treatment groups: group 1, 1 male control cat; group 2, 5 females administered 10 microg of GnR...

journal_title：Journal of reproductive immunology

authors： Robbins SC,Jelinski MD,Stotish RL

更新日期：2004-12-01 00:00:00

abstract：:Placental hypoxia following the immature remodeling of spiral arteries by extravillous cytotrophoblasts (CTs) is focused on the pathogenesis of pre-eclampsia. At the same time, the expression of human leukocyte antigen (HLA)-G is decreased at the protein and mRNA levels in the pre-eclamptic placenta. In view of the po...

journal_title：Journal of reproductive immunology

authors： Nagamatsu T,Fujii T,Yamashita T,Miki A,Kanai T,Kusumi M,Osuga Y,Kozuma S,Taketani Y

更新日期：2004-10-01 00:00:00

abstract：:There is increasing evidence to support the view that human parturition represents an inflammatory process. We have previously demonstrated that parturition is associated with leukocyte invasion and pro-inflammatory cytokine production in the cervix and myometrium. Furthermore, we have shown that several cell adhesion...

journal_title：Journal of reproductive immunology

authors： Osman I,Crawford M,Jordan F,Young A,Norman J,Thomson A

更新日期：2004-08-01 00:00:00

abstract：:Controversy exists as to whether active immunotherapy with allogeneic lymphocyte transfusions (ALT) or passive immunotherapy with intravenous immunoglobulin (IvIg) improve the chance of live birth in women with unexplained recurrent miscarriages (RM). Meta-analyses of the placebo-controlled trials carried out as Cochr...

journal_title：Journal of reproductive immunology

authors： Christiansen OB,Nielsen HS,Pedersen B

更新日期：2004-06-01 00:00:00

abstract：:Cytokines seem to play a critical role in the pathogenesis of unexplained recurrent pregnancy loss (RPL). Th1 cytokines have been shown to exert deleterious effects on pregnancy, inhibiting foetal growth and development. On the other hand, Th2 cytokines have been associated with successful pregnancy. The purpose of th...

journal_title：Journal of reproductive immunology

authors： Daher S,de Arruda Geraldes Denardi K,Blotta MH,Mamoni RL,Reck AP,Camano L,Mattar R

更新日期：2004-06-01 00:00:00

abstract：:Pharmacologic inhibition of indoleamine 2,3 dioxygenase (IDO) activity during murine pregnancy results in rejection of allogeneic fetuses by the maternal immune system. Here, we show that IDO expression is restricted to perinuclear regions of primary trophoblast giant cells (TGCs) of fetal origin at mid-gestation (E10...

journal_title：Journal of reproductive immunology

authors： Baban B,Chandler P,McCool D,Marshall B,Munn DH,Mellor AL

更新日期：2004-04-01 00:00:00

abstract：:The present investigation was undertaken to study the association between placental apoptosis and pre-eclampsia, discriminating between pre-eclamptic pregnancies with appropriate-, and small-for-gestational-age (SGA), infants. Twenty pregnancies with pre-eclampsia and SGA (birth weight at or below -2 standard deviatio...

journal_title：Journal of reproductive immunology

authors： Austgulen R,Isaksen CV,Chedwick L,Romundstad P,Vatten L,Craven C

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To express the hCGbeta-C3d3 fusion protein in a CHO cell continual expression system to investigate further the adjuvant effects of C3d on contraceptive vaccination. METHOD:We constructed a plasmid pcDNA3-hCGbeta-C3d3 which contains three copies of murine C3d cDNA and the hCGbeta gene by cloning the chimeric...

journal_title：Journal of reproductive immunology

authors： Li DJ,Wang HM,Li L,Zhao XR,Wang MY,Zhu Y,Meng Y,Yuan MM

更新日期：2003-12-01 00:00:00

abstract：:The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system all...

journal_title：Journal of reproductive immunology

authors： Saito S,Sakai M

更新日期：2003-08-01 00:00:00

abstract：:17 beta-estradiol induces rapid effects on cells of the immune system via plasma membrane surface receptor but the ways in which delayed signals involving intracellular receptors affect the same functions are not well understood. To study the delayed but sustained events in estradiol signaling, we have investigated ma...

journal_title：Journal of reproductive immunology

authors： Azenabor AA,Chaudhry AU

更新日期：2003-06-01 00:00:00

abstract：:This review will highlight recent advances in the study of the immuno-endocrinology of the testis, in particular how macrophage-derived inflammatory mediators affect Leydig cell functions. Both the beneficial and deleterious outcomes resulting from macrophage-Leydig cell interactions are discussed. A brief overview of...

journal_title：Journal of reproductive immunology

authors： Hales DB

更新日期：2002-10-01 00:00:00

abstract：:Establishment of pregnancy initiates a dynamic and predictable series of changes in the uterus. In rodents, the trophectoderm of the blastocyst develops through the stage of an ectoplacental cone to become the placenta. The inner cell mass becomes the fetus and its associated extra-embryonic ectoderm and mesoderm. Mat...

journal_title：Journal of reproductive immunology

authors： Croy BA,Chantakru S,Esadeg S,Ashkar AA,Wei Q

更新日期：2002-10-01 00:00:00

abstract：:Several members of the immunoglobulin-like transcript (ILT), also called leukocyte immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon binding of these ligands. The ligands for ILT2 (LIR1/CD...

journal_title：Journal of reproductive immunology

authors： Petroff MG,Sedlmayr P,Azzola D,Hunt JS

更新日期：2002-07-01 00:00:00

abstract：:The sequence of biochemical and molecular events associated with decidualization in the primate remain unclear. In the baboon, the sequential changes during this period in vivo are characterized by the downregulation of alpha-smooth actin followed by induction of cyclooxygenase-2 (COX-2) at the implantation site and t...

journal_title：Journal of reproductive immunology

authors： Strakova Z,Srisuparp S,Fazleabas AT

更新日期：2002-05-01 00:00:00

abstract：:For many years, experience has been accumulated on embryo and gamete manipulation in livestock animals. The present work is a review of these techniques and their possible application in human embryology in specific cases. It is possible to manipulate gametes at different levels, producing paternal or maternal haploid...

journal_title：Journal of reproductive immunology

authors： Escribá MJ,Valbuena D,Remohí J,Pellicer A,Simón C

更新日期：2002-05-01 00:00:00

abstract：:We sought to determine whether cytokine expression in peripheral blood mononuclear cells is altered in patients with preeclampsia and in patients with a history of recurrent spontaneous abortion (RSA). Twenty-four patients with preeclampsia and twenty patients with a history of RSA were included into the study. Two co...

journal_title：Journal of reproductive immunology

authors： Rein DT,Schondorf T,Gohring UJ,Kurbacher CM,Pinto I,Breidenbach M,Mallmann P,Kolhagen H,Engel H

更新日期：2002-03-01 00:00:00

abstract：:Development of a vaccine(s) based on sperm antigens represents a promising approach to contraception. The utility of an antigen in immunocontraception is contingent upon sperm/testis-specificity and its involvement in the fertilization process. Since, the sperm-zona pellucida (ZP) recognition and binding constitutes t...

journal_title：Journal of reproductive immunology

authors： Naz RK

更新日期：2002-01-01 00:00:00

abstract：:Following ejaculation, sperm functions are regulated by interactions with the environment found in the female genital tract. Here spermatozoa become 'capacitated' (i.e. they acquire the capability of completing the acrosome reaction and successfully fertilizing the egg), through a series of surface and intracellular t...

journal_title：Journal of reproductive immunology

authors： Baldi E,Luconi M,Bonaccorsi L,Forti G

更新日期：2002-01-01 00:00:00

abstract：:Focussing attention on cytokines at the materno-foetal interface represents one of the major advances made in the field. This owes much to the visionary views of Tom Wegmann, and to the changes brought about in the field by immunotrophism and Th1/Th2 paradigms. We review these briefly and also point out some emerging ...

journal_title：Journal of reproductive immunology

authors： Chaouat G,Zourbas S,Ostojic S,Lappree-Delage G,Dubanchet S,Ledee N,Martal J

更新日期：2002-01-01 00:00:00

abstract：:Despite immense effort, the development of vaccines effective at mucosal sites has proceeded at a faltering pace. Efforts concentrating on humoral immunity but neglecting cellular immunity may be misdirected by ignoring many viral mucosal pathogens. Improved understanding of the development and maintenance of lymphocy...

journal_title：Journal of reproductive immunology

authors： Gould DS,Ploegh HL,Schust DJ

更新日期：2001-10-01 00:00:00